Teun Bousema Selected Research

Primaquine

1/2022	Pyronaridine-artesunate or dihydroartemisinin-piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial.
10/2021	Model-based assessment of the safety of community interventions with primaquine in sub-Saharan Africa.
1/2021	G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials.
1/2020	Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether-lumefantrine.
8/2018	Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches.
3/2018	Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.
1/2018	Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial.
1/2018	Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials.
1/2017	Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children.
11/2016	The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial.

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Teun Bousema Research Topics

Disease

111	Malaria 03/2022 - 04/2006
46	Infections 12/2022 - 11/2008
28	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2022 - 04/2006
11	Hemolysis 10/2021 - 05/2010
10	Glucosephosphate Dehydrogenase Deficiency 10/2021 - 05/2009
5	Parasitemia 01/2022 - 12/2013
4	Anemia 10/2021 - 08/2009
3	Fever (Fevers) 11/2021 - 11/2008
2	Persistent Infection 12/2022 - 11/2021
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 01/2018
2	COVID-19 01/2022 - 07/2020
2	Onchocerciasis 01/2020 - 05/2013
2	Filarial Elephantiasis (Lymphatic Filariasis) 01/2020 - 05/2013
2	Body Weight (Weight, Body) 01/2017 - 05/2010
2	Asymptomatic Infections 03/2016 - 11/2008
1	Bites and Stings (Sting) 03/2022
1	Inflammation (Inflammations) 03/2022
1	Headache (Headaches) 01/2022
1	Convalescence 01/2022
1	Bacteremia 01/2021
1	Reinfection 01/2021
1	Vivax Malaria 10/2019
1	Fatigue 01/2018

Drug/Important Bio-Agent (IBA)

24	artemisinin (artemisinine)IBA 01/2022 - 04/2006
22	Pharmaceutical PreparationsIBA 01/2022 - 04/2006
21	Primaquine FDA Link 01/2022 - 05/2010
21	AntigensIBA 01/2022 - 05/2009
17	VaccinesIBA 01/2022 - 04/2011
16	AntibodiesIBA 12/2022 - 09/2008
16	Antimalarials (Antimalarial Agents)IBA 01/2022 - 10/2007
12	artenimol (dihydroartemisinin)IBA 01/2022 - 06/2013
12	piperaquineIBA 01/2022 - 06/2013
10	Ivermectin (Mectizan)FDA Link 01/2022 - 05/2013
10	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 10/2021 - 05/2010
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2015
7	pyrimethamine drug combination fanasil (Fansidar)FDA Link 03/2021 - 04/2006
7	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2019 - 03/2013
6	1- acetyl- 1,2,3,3a,8,8a- hexahydro- 8a- hydroxy- 5- methoxypyrrolo(2,3- b)indole (CHMI)IBA 03/2022 - 01/2018
6	EnzymesIBA 10/2019 - 08/2009
6	ArtesunateIBA 09/2016 - 04/2006
5	Biological ProductsIBA 01/2022 - 07/2014
5	Merozoite Surface Protein 1 (MSA1)IBA 04/2015 - 05/2009
4	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 08/2013
3	Monoclonal AntibodiesIBA 12/2021 - 01/2016
3	Hemoglobins (Hemoglobin)IBA 10/2021 - 11/2016
3	Amodiaquine (Camoquin)FDA Link 03/2021 - 03/2015
3	Indicators and Reagents (Reagents)IBA 12/2020 - 01/2012
3	InsecticidesIBA 11/2020 - 04/2016
3	Malaria VaccinesIBA 01/2020 - 05/2014
2	CytokinesIBA 03/2022 - 09/2004
2	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2017
2	von Willebrand FactorIBA 01/2022 - 11/2015
2	artesunate drug combination pyronaridine tetraphosphateIBA 01/2022 - 06/2018
2	glucose-6-phosphate dehydrogenase A-IBA 01/2021 - 05/2010
2	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 08/2015
2	3-O-(methylthiomethyl)apiitol tetraacetateIBA 10/2020 - 08/2019
2	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 10/2019 - 03/2018
2	methyl 1- ribofuranosyl- 1,2,4- triazole- 3- carboxamidateIBA 01/2018 - 06/2016
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 08/2017 - 01/2015
2	ArtemisininsIBA 12/2014 - 05/2010
2	Immunoglobulin G (IgG)IBA 08/2013 - 01/2012
1	Interleukin-8 (Interleukin 8)IBA 03/2022
1	Interleukin-6 (Interleukin 6)IBA 03/2022
1	AnticoagulantsIBA 01/2022
1	Sodium Citrate FDA LinkGeneric 01/2022
1	Thrombin FDA Link 01/2022
1	LithiumIBA 01/2022
1	tafenoquineIBA 01/2022
1	P-SelectinIBA 01/2022
1	EpitopesIBA 01/2022
1	Heparin (Liquaemin)FDA LinkGeneric 01/2022
1	Edetic Acid (EDTA)FDA Link 01/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 11/2021
1	18S Ribosomal RNAIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	NucleotidesIBA 01/2021
1	8-aminoquinolineIBA 12/2020
1	BuffersIBA 11/2020
1	di-n-hexyl sulfosuccinate (DHSS)IBA 10/2020
1	Antiviral Agents (Antivirals)IBA 07/2020
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 07/2020
1	Azithromycin (Zithromax)FDA LinkGeneric 07/2020
1	Immune Sera (Antisera)IBA 01/2019
1	Heme (Haem)IBA 07/2018
1	Interleukin-10 (Interleukin 10)IBA 07/2018
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2018
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018
1	HaptoglobinsIBA 01/2018
1	AldehydesIBA 01/2018
1	Alanine Transaminase (SGPT)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2017
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2017
1	Nucleic AcidsIBA 12/2015

Therapy/Procedure

24	Therapeutics 01/2022 - 04/2006
15	Mass Drug Administration 01/2022 - 05/2010
8	Aftercare (After-Treatment) 01/2022 - 04/2006
3	Chemoprevention 03/2021 - 12/2019
2	Intravenous Administration 03/2022 - 10/2021
1	Prenatal Care (Care, Prenatal) 12/2019
1	Drug Therapy (Chemotherapy) 01/2017